Welcome to the Oh Laboratory
Pharmacology Department at the University of Colorado School of Medicine, Anschutz Medical Campus 

Neocortical neurons receive thousands of excitatory and inhibitory synaptic inputs driven by varying patterns of neuronal activity. The spatial arrangement and temporal regulation of excitatory and inhibitory synapses determine the functional consequences of excitation and inhibition for synaptic integration, action potential generation, and neural activity.

We use advanced optical imaging techniques to examine the spatiotemporal mechanisms that govern activity-dependent excitatory and inhibitory synaptic and circuit plasticity in the developing cortex.